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miRNAs and ovarian cancer: An overview

Bornali Deb1, Arif Uddin2, Supriyo Chakraborty1

  • 1Department of Biotechnology, Assam University, Silchar, India.

Journal of Cellular Physiology
|July 14, 2017
PubMed

Insights

MicroRNAs (miRNAs) are key regulators of gene expression in ovarian cancer (OC). Understanding miRNA roles offers new avenues for OC detection, diagnosis, and treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Ovarian cancer (OC) is a leading cause of cancer death in women globally.
  • Despite advances, OC remains a dangerous gynecologic malignancy.
  • MicroRNAs (miRNAs) are small noncoding RNAs regulating gene expression and are implicated in cancer.

Purpose of the Study:

  • To review the current understanding of miRNA expression in OC.
  • To explore the clinical relevance of circulating miRNAs for OC.
  • To highlight the potential of miRNAs in OC diagnosis, prognosis, and therapy.

Main Methods:

  • Literature review of studies on miRNA expression in ovarian cancer.
  • Analysis of research on the diagnostic and prognostic potential of circulating miRNAs.
  • Examination of therapeutic strategies involving miRNAs in OC.

Main Results:

  • miRNAs play a significant role in regulating genes involved in OC development.
  • Circulating miRNAs show promise as biomarkers for OC diagnosis and prognosis.
  • Identifying functional miRNA targets remains a challenge but is progressing.

Conclusions:

  • miRNA expression is crucial in ovarian cancer.
  • Circulating miRNAs offer potential for improved OC clinical management.
  • Further research into miRNA function may lead to novel OC detection and therapeutic strategies.
Keywords:
gynecologic malignancymiRNAovarian cancer

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