Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.9K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incidence and Factors Associated With In-Hospital Mortality in Adult Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Nationwide Thai Cohort.

Journal of cutaneous medicine and surgery·2026
Same author

Association of initial diagnostic setting and referral delay with mortality in systemic sclerosis: a nationwide database cohort study.

BMC primary care·2026
Same author

Incidence Trends and Severe in-Hospital Outcomes of Pemphigus Vulgaris: A Nationwide Cohort Study.

The Journal of dermatology·2026
Same author

Hair Loss Associated With IL-17 and IL-23 Inhibitors: A Systematic Review.

International journal of dermatology·2026
Same author

Role of Probiotics in Managing Acne Vulgaris: A Systematic Review and Meta-Analysis of Clinical Trials.

Journal of cutaneous medicine and surgery·2026
Same author

Efficacy and Safety of Imsidolimab for Generalized Pustular Psoriasis.

NEJM evidence·2026

Related Experiment Video

Updated: Feb 26, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K

Phototherapy in systemic sclerosis: Review.

Suteeraporn Chaowattanapanit1, Charoen Choonhakarn1, Chingching Foocharoen2

  • 1Division of Dermatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Photodermatology, Photoimmunology & Photomedicine
|July 14, 2017
PubMed
Summary

Phototherapy using ultraviolet A (UVA) shows promise for treating skin sclerosis in systemic sclerosis (SSc) patients. This approach may improve skin condition, joint mobility, and heal ulcers, offering a potential new treatment option.

Keywords:
pathogenesisphototherapysystemic sclerosistreatment outcomeultraviolet A

More Related Videos

Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

43.0K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.1K

Related Experiment Videos

Last Updated: Feb 26, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.6K
Minimal Erythema Dose MED Testing
06:24

Minimal Erythema Dose MED Testing

Published on: May 28, 2013

43.0K
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
03:20

Studying Chronic Exposure of Mice to Ultraviolet B Radiation

Published on: August 19, 2025

2.1K

Area of Science:

  • Dermatology
  • Rheumatology
  • Immunology

Background:

  • Systemic sclerosis (SSc) is a chronic connective tissue disease causing skin and organ fibrosis.
  • Current antifibrotic treatments for SSc often yield unsatisfactory results.
  • Skin sclerosis in SSc significantly impacts patient quality of life and function.

Purpose of the Study:

  • To evaluate the efficacy of phototherapy, specifically ultraviolet A (UVA), in treating skin sclerosis in patients with systemic sclerosis (SSc).
  • To explore the therapeutic mechanisms of UVA phototherapy in managing SSc manifestations.

Main Methods:

  • Review of studies utilizing psoralen plus UVA (PUVA) and UVA1 phototherapy for SSc.
  • Analysis of clinical outcomes, including skin sclerosis, joint mobility, and digital ulcers.
  • Examination of histopathological changes and proposed mechanisms of action.

Main Results:

  • Phototherapy, including PUVA and UVA1, demonstrated satisfactory results in treating skin sclerosis.
  • Improvements were observed in skin softening, joint mobility, and healing of digital ulcers.
  • Mechanisms involve lymphocyte apoptosis, altered cytokines, reduced collagen synthesis, and enhanced collagenase production.

Conclusions:

  • PUVA and UVA1 phototherapy represent a potential alternative or adjunctive treatment for SSc patients.
  • Phototherapy offers a promising approach to manage skin sclerosis and related complications in SSc.
  • Further research may solidify the role of phototherapy in the multidisciplinary management of SSc.