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Updated: Feb 26, 2026

The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
Published on: February 12, 2015
Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89
L Allott1, C Da Pieve1, J Meyers2
1Division of Radiotherapy and Imaging, The Institute of Cancer Research, 123 Old Brompton Road, London, UK. graham.smith@icr.ac.uk.
Abstract:
The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for 89Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with 89Zr. This work broadens the selection of available chelators for 89Zr in search of improved successors to DFO for clinical 89Zr-immuno-PET.
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