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A New Murine Model of Endovascular Aortic Aneurysm Repair
Published on: July 7, 2013
[Surgical and endoluminal management of the inflammatory aortitis: A Tunisian center experience]
H Ben Jmaà1, R Karray1, H Jmal1
1Service de chirurgie cardiovasculaire et thoracique, hôpital Habib Bourguiba, 3029 Sfax, Tunisie.
Insights
Giant-cell arteritis, Takayasu disease, and Behçet disease cause non-infectious aortitis, often leading to aortic aneurysms. Management involves surgery or endovascular repair, with regular aortic monitoring crucial due to aneurysm frequency.
Area of Science:
- Vascular Surgery
- Rheumatology
- Cardiology
Background:
- Non-infectious aortitis commonly results from giant-cell arteritis, Takayasu disease, or Behçet disease.
- Aortic lesions include stenoses, occlusions, and aneurysms, varying by disease etiology.
- Current treatment paradigms combine corticosteroid therapy, surgery, and increasingly, endoluminal interventions.
Purpose of the Study:
- To retrospectively analyze the outcomes of surgical and endoluminal management for inflammatory aortic lesions.
- To evaluate treatment strategies in patients with Takayasu disease and Behçet disease affecting the aorta.
Main Methods:
- Retrospective descriptive study of 10 patients treated between January 2000 and December 2015.
- Inclusion criteria: patients with inflammatory aortic lesions managed surgically or endoluminally.
- Data collected on disease type, aortic lesion characteristics, treatment modality, and patient outcomes.
Main Results:
- The study included 4 cases of Takayasu disease and 6 cases of Behçet disease.
- Behçet disease patients predominantly presented with aneurysmal lesions; Takayasu disease patients had predominantly occlusive lesions.
- Surgical management was employed in 4 Behçet disease patients and all Takayasu disease patients, while 2 Behçet disease patients underwent endovascular repair.
- Mortality included 2 postoperative deaths and 2 deaths during long-term follow-up.
Conclusions:
- Aortic aneurysms are a frequent complication requiring diligent screening and lifelong monitoring.
- Both surgical and endovascular approaches have a role in managing inflammatory aortitis, but outcomes require careful consideration.
- Long-term surveillance is essential for patients with inflammatory aortic diseases due to the high risk of aneurysm formation and progression.
Abstract:
Non-infectious aortitis is usually due to giant-cell arteritis, Takayasu disease or Behçet disease. The main aortic lesions are stenoses, occlusions and aneurysms in the Takayasu disease and aneurysms in the Behçet disease and giant-cell arteritis. Treatment is based on corticosteroid therapy and surgery. Endoluminal management is now the rule. We report a retrospective descriptive study of 10 patients who underwent surgical or endoluminal management of inflammatory lesions of the aorta between January 2000 and December 2015. There were 4 cases of Takayasu disease and 6 cases of Behçet disease. The aortic lesions were aneurysmal in all of the patients with Behçet disease. In the patients with Takayasu disease, aortic occlusions predominated, associated with other arterial lesions. Four patients with Behçet disease were managed surgically, and 2 patients underwent endovascular repair. All of the patients with Takayasu disease underwent surgery. Two patients died in the postoperative period, and two patients died during long-term follow-up. Systematic screening, as well as regular monitoring of the entire aorta during the follow-up, is necessary due to the frequency of aortic aneurysms.
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