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Updated: Feb 26, 2026

Cardiac Response to β-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis
Published on: May 19, 2021
Inadvertent cardiac phlebography
Konstantinos Aznaouridis1, Constantina Masoura1, Stylianos Kastellanos1
1Konstantinos Aznaouridis, Constantina Masoura, Stylianos Kastellanos, Albert Alahmar, Cardiology Department, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, United Kingdom.
Insights
A case report highlights a potential risk during left ventriculograms using radial catheters. A normal pressure waveform does not guarantee correct catheter placement, as seen in this effort angina patient.
Area of Science:
- Cardiology
- Interventional Cardiology
- Diagnostic Imaging
Background:
- Coronary angiography is a key diagnostic tool for patients with suspected or known coronary artery disease.
- Left ventriculography is performed to assess left ventricular function and morphology during coronary angiography.
- Radial artery access is increasingly preferred for its safety and patient comfort.
Observation:
- A dedicated radial multipurpose 5 French Optitorque Tiger catheter was used for coronary angiography and left ventriculography in an 80-year-old female with effort angina.
- The catheter was advanced into the left ventricle, and a left ventriculogram was obtained.
- Despite an apparently optimal catheter position and normal pressure waveform, the catheter's end hole inadvertently cannulated an endocardial opening of a thebesian vein.
Findings:
- Opacification of a large posterior interventricular vein draining into the right atrium occurred.
- This opacification was attributed to retrograde filling of the epicardial vein via the thebesian vein.
- The findings suggest potential catheter malposition despite a normal left ventricular pressure waveform.
Implications:
- Caution is advised when using radial catheters with both end-holes and side holes for ventriculography.
- A normal left ventricular pressure waveform may not reliably exclude inadvertent catheter engagement with endocardial structures.
- This case underscores the importance of meticulous technique and awareness of potential complications during interventional cardiology procedures.
Abstract:
We are reporting a case of a 80-year-old lady with effort angina who underwent coronary angiography through the right radial artery, using a dedicated radial multipurpose 5 French Optitorque Tiger catheter. The catheter was advanced into the left ventricle and a left ventriculogram was obtained, while the catheter appeared optimally placed at the centre of the ventricle and the pressure waveform was normal. A large posterior interventricular vein draining into the right atrium was opacified, presumably because the catheter's end hole inadvertently cannulated an endocardial opening of a small thebesian vein, with subsequent retrograde filling of the epicardial vein. Our case suggests that caution is needed when a dedicated radial catheter with both an end-hole and a side hole is used for a ventriculogram, as a normal left ventricular pressure waveform does not exclude malposition of the end-hole against the ventricular wall.
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Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...

