Related Experiment Video
Updated: Feb 26, 2026
03:53
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
1.2K
Microbiome in chronic obstructive pulmonary disease
1Respiratory Diseases Department, Parc Taulí University Hospital, Sabadell, Barcelona, Spain.
Annals of Translational Medicine
|July 15, 2017
Summary
Tobacco smoke alters the respiratory microbiome, causing dysbiosis. Chronic obstructive pulmonary disease (COPD) exacerbations involve microbial shifts and altered metabolic pathways, impacting overall lung health.
Area of Science:
- Microbiology
- Pulmonology
- Genomics
Background:
- The respiratory system harbors a diverse microbiome.
- Tobacco smoke exposure induces oropharyngeal dysbiosis in smokers.
- Chronic obstructive pulmonary disease (COPD) is associated with reduced bacterial diversity and shifts in microbial composition.
Purpose of the Study:
- To investigate the impact of tobacco smoke and COPD on the respiratory microbiome.
- To understand microbial dynamics during COPD exacerbations.
- To explore functional genomic changes in the bronchial microbiome during exacerbations.
Main Methods:
- Culture-independent techniques for microbiological analysis of respiratory samples.
- Sputum microbiome analysis in COPD patients.
- Functional metagenomics to assess genomic potential.
Main Results:
- Tobacco smoke alters the oropharyngeal microbiome, increasing certain bacterial genera.
- COPD sputum samples show decreased diversity, with Proteobacteria overrepresentation and Firmicutes decline.
- Exacerbations can involve uncultured pathogens, while colonizers persist.
- Functional metagenomics reveals altered metabolic pathways, including carbohydrate metabolism and cell growth, during exacerbations.
Conclusions:
- Respiratory microbiome analysis is crucial for understanding lung diseases.
- COPD exacerbations are linked to significant microbial and functional shifts.
- The respiratory microbiome's functional capacity plays a role in disease pathogenesis.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.9K
01:24Chronic Obstructive Pulmonary Disease
2.8K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
2.8K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
4.0K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
4.0K
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.2K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.2K
01:29Chronic Obstructive Pulmonary Disease-V: Management
3.3K
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
3.3K
01:20COPD: Pathogenesis and Clinical Features
2.0K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.0K