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Complexity transmission during replication.

B K Davis

    Proceedings of the National Academy of Sciences of the United States of America
    |May 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Complexity, measured as molecular randomness, decreases during DNA to protein transmission. This finding suggests complexity dictates molecular transformations and evolution requires non-deterministic mechanisms for increases.

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    Area of Science:

    • Molecular Biology
    • Biophysics
    • Information Theory

    Background:

    • Understanding molecular complexity is crucial for deterministic biological processes like DNA replication.
    • Quantifying randomness within ordered molecular structures provides insights into biological information transfer.

    Purpose of the Study:

    • To investigate the transmission of molecular complexity during DNA replication.
    • To determine the role of complexity in molecular interactions and biological evolution.

    Main Methods:

    • Defined complexity as the entropy of a posteriori probabilities for discrete and continuous structural parameters.
    • Analyzed sequence complexity changes from DNA to protein.
    • Examined complexity limits in polypeptide folding and protein-ligand interactions.

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  • Applied theoretical analysis and validated with experimental data.

    • Main Results:

    • Sequence complexity decreases from DNA to protein.
    • Molecular complexity limits polypeptide folding and protein-ligand interactions.
    • In deterministic processes, cause exhibits higher complexity than effect, aligning with Curie's symmetry principle.

    Conclusions:

    • Complexity governs the direction of order-order molecular transformations.
    • DNA replication's stepwise nature is a consequence of complexity constraints.
    • Evolutionary increases in complexity necessitate non-deterministic mechanisms.