Hereditary blood coagulation factor-VII deficiency in the beagle: immunological characterisation of the defect

In the plasma of beagles known to be homozygotes for hereditary blood coagulation factor-VII deficiency, antibody neutralization assays indicate only slightly greater quantities of factor-VII related antigen than are detected by conventional assays of procoagulant activity. Plasma of one dog was depleted of factor-VII procoagulant activity by exposure to an immobilized antibody; the low level of activity originally present was then verified by titration with normal plasma. The plasma defect results from an incomplete deletion of synthesis.