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Related Experiment Video

Updated: Feb 26, 2026

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
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Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

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Bronchial hyper-responsiveness after preterm birth.

Hege H Clemm1, Merete Engeseth2, Maria Vollsæter1

  • 1Department of Pediatrics, Haukeland University Hospital, Bergen, Norway.

Paediatric Respiratory Reviews
|July 16, 2017
PubMed
Summary
This summary is machine-generated.

Preterm birth can impair lung function, leading to airway obstruction and bronchial hyperresponsiveness (BHR). These symptoms in preterm infants differ from asthma and may not involve eosinophilic inflammation.

Keywords:
Bronchial hyperresponsivenessBronchopulmonary dysplasiaChronic lung disease of prematurityHistamineInfantMethacholinePremature

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Area of Science:

  • Pulmonary Medicine
  • Neonatology
  • Pediatric Respiratory Health

Background:

  • Preterm birth frequently impacts long-term lung function, often presenting with airway obstruction and bronchial hyperresponsiveness (BHR).
  • While symptoms can mimic asthma, lung disease post-preterm birth is recognized as a distinct entity.
  • Bronchial hyperresponsiveness (BHR) is characteristic of asthma but also present in other respiratory conditions and asymptomatic individuals.

Purpose of the Study:

  • To review methods for assessing BHR.
  • To synthesize findings from studies investigating BHR in individuals born preterm.
  • To identify knowledge gaps and understand the characteristics of BHR in this population.

Main Methods:

  • Systematic review of literature on BHR assessment methods.
  • Analysis of findings from studies examining BHR in preterm-born subjects.
  • Comparison of BHR characteristics in preterm-born individuals versus other groups.

Main Results:

  • The field of BHR post-preterm birth is understudied, with limited and heterogeneous research.
  • BHR in preterm infants appears associated with lower gestational age and a history of bronchopulmonary dysplasia.
  • No studies linked BHR in preterm individuals to eosinophilic airway inflammation markers typical of asthma.

Conclusions:

  • BHR in preterm-born individuals is a distinct clinical issue, separate from asthma.
  • Gestational age and bronchopulmonary dysplasia are potential contributing factors to BHR.
  • Treatment of preterm-born individuals with BHR and airway symptoms should consider the absence of typical asthma inflammatory markers.