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In vitro interactions between teicoplanin and other antibiotics against enterococci and staphylococci

E Debbia, A Pesce, G C Schito

    The Journal of Hospital Infection
    |March 1, 1986
    PubMed

    Insights

    This study investigated teicoplanin combinations against bacteria. Teicoplanin showed synergistic effects with fosfomycin and imipenem, with no antagonistic interactions observed.

    Area of Science:

    • Microbiology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Teicoplanin is a key antibiotic for treating Staphylococcal and Enterococcal infections.
    • Understanding drug interactions is crucial for optimizing antimicrobial therapy.
    • Evaluating novel antibiotic combinations can improve treatment efficacy.

    Purpose of the Study:

    • To assess the in vitro activity of teicoplanin in combination with other antibiotics.
    • To determine the interaction profiles (synergism, indifference, antagonism) of these combinations.
    • To identify effective combination therapies against resistant bacterial strains.

    Main Methods:

    • Utilized a microtitre checkerboard dilution method to evaluate drug interactions.
    • Employed a time-kill test to confirm synergistic or antagonistic effects.
    • Tested combinations including teicoplanin with rifampicin, netilmicin, amikacin, fosfomycin, and imipenem.

    Main Results:

    • Teicoplanin combined with rifampicin showed mostly indifferent or additive effects.
    • Synergism was observed with netilmicin and amikacin against some enterococcal strains, but indifference was common with staphylococcal isolates.
    • Predominant synergism was noted when teicoplanin was combined with fosfomycin and imipenem.
    • No antagonistic effects were detected with any drug combination.

    Conclusions:

    • Teicoplanin-fosfomycin and teicoplanin-imipenem combinations demonstrate promising synergistic activity.
    • Combination therapy with teicoplanin does not appear to produce antagonistic effects.
    • These findings support further investigation into teicoplanin-based combination therapies for challenging infections.

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