Related Experiment Video
Updated: Jul 23, 2026
Video-oculography in Mice
Published on: July 19, 2012
Video-oculography in multiple sclerosis: Links between oculomotor disorders and brain magnetic resonance imaging
1Unité de Recherche Clinique - Centre Mémoire, chef de service Pr Pesce, Centre de Gérontologie Clinique RAINIER III, Centre Hospitalier Princesse Grace, Avenue Pasteur, 98000 Monaco, Monaco.
Background:
Eye movement abnormalities (EMA) are common in multiple sclerosis (MS). However, type and severity according to the MS stage are poorly known, especially in Radiologically Isolated Syndrome (RIS) and in Clinically Isolated Syndrome (CIS). Although MRI has been included in the MS diagnostic criteria, there may be clinical-radiological dissociation.
Objective:
To analyze by video-oculography (VOG) prevalence of EMA in different MS phenotypes and study correlations with brain and cervical cord MRI T2 lesions location.
Methods:
76 participants were prospectively recruited (12 RIS, 10 CIS, 11 relapsing-remitting-MS, 10 secondary progressive-MS, 10 primary progressive MS and 23 gender and age-matched healthy controls). We analyzed fixations, anti-saccades, horizontal and vertical reflex saccades and smooth pursuit.
Results:
EMA were frequent and of gradual severity from RIS to progressive forms. Internuclear ophthalmoplegia (INO) and centripetal hypermetria were strong arguments for the diagnosis of a demyelinating disorder versus a control population. Some EMA were linked to infratentorial T2 lesion location, but others like INO were not.
Conclusion:
This study confirm that EMA are common in all MS phenotypes, even at the earliest stages. VOG can be useful to detect demyelinating process at preclinical stage by highlighting subclinical EMA even in absence of characteristic lesions visible on MRI.
Insights
Eye movement abnormalities are common in all stages of multiple sclerosis (MS), even in preclinical phases. Video-oculography (VOG) can detect these subclinical abnormalities, aiding in early diagnosis of MS.
Area of Science:
- Neuro-ophthalmology
- Neurology
- Medical imaging
Background:
- Eye movement abnormalities (EMA) are prevalent in multiple sclerosis (MS) but their characteristics across different disease stages, particularly in early phases like Radiologically Isolated Syndrome (RIS) and Clinically Isolated Syndrome (CIS), are not well understood.
- Despite MRI's role in MS diagnosis, clinical-radiological dissociation can occur, highlighting the need for complementary diagnostic tools.
Purpose of the Study:
- To investigate the prevalence of EMA using video-oculography (VOG) across various MS phenotypes.
- To explore the relationship between EMA and the location of T2 lesions in the brain and cervical cord.
Main Methods:
- Prospective recruitment of 76 participants, including individuals with RIS, CIS, relapsing-remitting MS, secondary progressive MS, primary progressive MS, and healthy controls.
- Comprehensive analysis of ocular motor functions: fixations, anti-saccades, horizontal and vertical reflex saccades, and smooth pursuit using VOG.
Main Results:
- EMA were frequently observed and showed increasing severity from RIS to progressive MS forms.
- Internuclear ophthalmoplegia (INO) and centripetal hypermetria were identified as key indicators of demyelinating disease.
- While some EMA correlated with infratentorial T2 lesions, others like INO did not show this correlation.
Conclusions:
- EMA are common in all MS phenotypes, including the earliest stages, confirming their utility in MS assessment.
- VOG is a valuable tool for detecting subclinical EMA, potentially identifying the demyelinating process even before characteristic MRI lesions are visible, aiding in preclinical diagnosis.
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