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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Nephrotic Syndrome I : Introduction01:24

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Related Experiment Video

Updated: Feb 26, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Diabetic Nephropathy and Pregnancy.

Kate Bramham1

  • 1Division of Transplantation and Mucosal Biology, King's College London, London, UK.

Seminars in Nephrology
|July 17, 2017
PubMed
Summary

Pregnancies in women with diabetic nephropathy present significant risks, leading to poor maternal and fetal outcomes. This review explores evidence and optimization strategies for managing these challenging pregnancies.

Area of Science:

  • Nephrology
  • Obstetrics
  • Endocrinology

Background:

  • Diabetic nephropathy complicates pregnancies, resulting in adverse maternal and fetal outcomes.
  • Mechanisms of adverse events are poorly understood but likely involve endothelial injury.
  • High rates of maternal hypertension, preeclampsia, and cesarean delivery are observed.

Purpose of the Study:

  • To review current evidence on maternal and fetal outcomes in women with diabetic nephropathy.
  • To describe optimization strategies for prepregnancy, antenatal, and peripartum care.

Main Methods:

  • Literature review of existing evidence on pregnancy outcomes in diabetic nephropathy.
  • Synthesis of data on maternal and fetal complications.
  • Identification and description of management strategies.
Keywords:
Diabetesnephropathypreeclampsiapregnancy

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Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
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Main Results:

  • Pregnancy outcomes are worse than expected for the stage of chronic kidney disease.
  • Offspring are frequently preterm and low birth weight, with neonatal complications.
  • Glycemic control significantly impacts neonatal outcomes.

Conclusions:

  • Diabetic nephropathy poses substantial risks during pregnancy.
  • Prepregnancy, antenatal, and peripartum optimization are crucial for improving outcomes.
  • Further research into underlying mechanisms is needed to enhance management strategies.