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Enhanced serum concentrations of Ara-C using suppositories containing tetrahydrouridine as a deamination inhibitor of
The Journal of Pharmacy and Pharmacology
|March 1, 1986
Abstract:
Rectal bioavailability of Ara-C (serum AUC 4 h: 65 micrograms h-1 ml-1) administered in a suppository formulation containing tetrahydrouridine (a deamination inhibitor) and sodium salicylate (an adjuvant) to dogs was better than that from a suppository formulation without tetrahydrouridine (serum AUC 4 h: 18 micrograms h-1 ml-1).