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The Effect of Targeted Therapy for Genitourinary Malignancies on Sexual Function and Fertility

Bradley C Holland1, Zubin Shetty2, Shaheen Alanee3

  • 1Department of Surgery, Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, USA.

Current Urology Reports
|July 17, 2017
PubMed
Abstract

Insights

Targeted therapies for genitourinary cancers offer survival benefits but may impact sexual function. mTOR inhibitors may affect testosterone and semen, while tyrosine kinase inhibitors (TKIs) show no adverse sexual outcomes.

Area of Science:

  • Oncology
  • Urology
  • Pharmacology

Background:

  • Targeted therapy use is increasing for genitourinary (GU) cancers.
  • These treatments improve survival but have limited long-term adverse effect data.
  • Quality of life, particularly sexual function, is crucial for long-term cancer survivors.

Purpose of the Study:

  • To review the impact of targeted therapies on sexual function in genitourinary cancer patients.
  • To identify potential adverse sexual effects associated with specific targeted drug classes.
  • To highlight the need for discussing sexual health in cancer care.

Main Methods:

  • Literature review of targeted therapies for GU cancers.
  • Analysis of studies reporting on sexual function outcomes.
  • Examination of drug class-specific effects on sexual health.

Main Results:

  • mTOR inhibitors may affect testosterone levels and semen parameters.
  • Tyrosine kinase inhibitors (TKIs) have not been linked to adverse sexual outcomes in current literature.
  • Laboratory studies suggest potential benefits of tyrosine kinases for erectile function.

Conclusions:

  • Sexual side effects of targeted therapies for GU cancer require careful patient discussion.
  • Further research is needed to elucidate mechanisms and long-term outcomes of sexual function with emerging targeted therapies.
Keywords:
FertilityGenitourinary cancerMen’s healthSexual functionTargeted therapymTOR inhibitors

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