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Published on: November 3, 2018
Frequency And Pattern Of Bone Marrow Involvement Among Patients With Non Hodgkin Lymphoma.
Umar Zahur1, Lubna Zafar1, Sehar Khaliq1
1Department of Pathology, Fauji Foundation Hospital, Foundation University Medical College, Rawalpindi, Pakistan.
Bone marrow involvement is common in newly diagnosed Non-Hodgkin lymphoma (NHL), with a diffuse pattern frequently observed. This finding on trephine biopsy indicates a poor prognosis for patients.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Non-Hodgkin lymphoma (NHL) is a diverse lymphoid neoplasm with potential extranodal spread.
- Bone marrow involvement is a critical staging factor in NHL.
- Understanding NHL bone marrow patterns aids in prognosis.
Purpose of the Study:
- To determine the frequency of bone marrow involvement in NHL.
- To analyze the patterns of bone marrow infiltration in NHL.
- To correlate bone marrow biopsy findings with NHL staging.
Main Methods:
- A cross-sectional study was conducted on 106 NHL patients.
- Patients had confirmed NHL via lymph node biopsy and no prior chemotherapy.
- Bone marrow trephine biopsies were performed for staging.
Main Results:
- Bone marrow involvement was detected in 42.5% of patients.
- The most frequent pattern was diffuse infiltration (44.44%).
- Other patterns included interstitial (28.89%), focal (11.11%), and mixed (11.11%).
Conclusions:
- Newly diagnosed NHL frequently involves the bone marrow.
- A diffuse pattern of bone marrow infiltration is common.
- Bone marrow involvement in NHL suggests a poorer prognosis.
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