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Expansion and Enrichment of Gamma-Delta γδ T Cells from Apheresed Human Product
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Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Myriam Lawand1,2,3, Julie Déchanet-Merville4, Marie-Caroline Dieu-Nosjean1,2,3

  • 1Cordeliers Research Center, UMRS 1138, Team "Cancer, Immune Control and Escape", INSERM, Paris, France.

Frontiers in Immunology
|July 18, 2017
PubMed

The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on the main characteristics of human γδ T-cell subsets in diseases and the key mechanisms that could be explored to target these cells.

Keywords:
NK receptorantigen presentationautoimmunitycancercytokinecytotoxicityhuman gamma-delta T cellinfection

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