Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation

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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Noémi Klára Tóth1, Zoltán Csanádi2, Orsolya Hajas2

  • 1Division of Clinical Laboratory Sciences, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Biomed Research International
|July 18, 2017
PubMed

Insights

Atrial fibrillation (AF) patients showed elevated Factor VIII and von Willebrand factor, likely from endothelial damage. No significant intracardiac hemostasis or fibrinolysis abnormalities were found in AF patients compared to controls.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Thrombosis Research

Background:

  • Atrial fibrillation (AF) is linked to thromboembolism.
  • Intracardiac hemostasis and fibrinolysis abnormalities may contribute to AF-related risks.

Purpose of the Study:

  • To investigate intracardiac hemostasis and fibrinolysis in patients with AF.
  • To identify potential abnormalities associated with AF and thromboembolic risk.

Main Methods:

  • Blood samples were collected from the femoral vein, left atrium, and left atrial appendage in 24 AF patients and 14 controls.
  • Assays measured fibrinogen, factor VIII (FVIII), von Willebrand factor (VWF), thrombin-antithrombin (TAT) complex, fibrin monomer (FM), plasminogen, α2-plasmin inhibitor, plasmin-α2-antiplasmin (PAP) complex, PAI-1 activity, and D-dimer.

Main Results:

  • AF patients exhibited significantly elevated FVIII and VWF levels in both femoral vein and left atrium compared to controls.
  • TAT complex, FM, PAP complex, and D-dimer were elevated in the left atrium versus femoral vein in both groups, suggesting procedural thrombotic risk.

Conclusions:

  • No significant intracardiac hemostasis or fibrinolysis alterations were identified in AF patients compared to non-AF controls.
  • Elevated FVIII and VWF levels in AF patients suggest systemic endothelial damage, affecting both intracardiac and systemic circulation.
Abstract

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