![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
Uric acid and dehydration in children with gastroenteritis
Rie Kuge1, Yoshihiko Morikawa2, Yukihiro Hasegawa3
1Support Center for Children and Family, Department of Psychology and Welfare, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan.
Summary
Serum uric acid (UA) can help assess dehydration severity in children with acute gastroenteritis (AGE). This study found a significant correlation between serum UA levels and weight loss, indicating its potential as a clinical assessment tool.
Area of Science:
- Pediatrics
- Biochemistry
- Clinical Medicine
Background:
- Clinical assessment of dehydration in children with acute gastroenteritis (AGE) is critical for effective treatment.
- Acute weight loss is the gold standard for assessing dehydration severity.
- Serum urea nitrogen (UN) correlates with dehydration severity but is influenced by nutritional status.
Purpose of the Study:
- To investigate the relationship between serum uric acid (UA) and weight loss in children with AGE.
- To evaluate serum UA as a potential alternative marker for dehydration severity.
Main Methods:
- Prospective observational study conducted from December 2010 to March 2015.
- Included 97 children aged 1-71 months admitted with AGE.
- Used pre-post-rehydration weight change as the gold standard for dehydration assessment.
Main Results:
- Serum UA levels showed a significant positive correlation with weight change.
- Serum UA levels increased significantly with increasing dehydration severity.
Conclusions:
- Serum uric acid (UA) shows promise as an adjunct marker for assessing dehydration in children with AGE.
- Further research may validate UA as a reliable indicator of dehydration severity.
More Related Videos
Related Concept Videos
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
485
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
485
01:14Prevention of Further Absorption of Poison
1.3K
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
1.3K
01:30Urinary Tract Calculi III: Medical Management
303
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
303
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
478
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
478
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
376
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
376
01:28Urinary Tract Calculi V: Nursing Management
372
AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...
372