[ARNI, new abbreviation for a new class of treatment of heart failure]
Soran Karimzadeh1, Hazrije Mustafić1, Tomoe Stampfli Andres1
1Service de cardiologie non invasive, Hôpital de La Tour, 1217 Meyrin.
Abstract:
ARNI (Angiontensin Receptor Neprilysin Inhibitor) are a new class of drug : the angiotensin and neprilysin inhibitors. This combined effect allows an optimisation of the heart failure treatment by acting on both pathways of the renin-angiotensin-aldosterone and of the natriuretic peptides. LCZ696 is a combined molecule of valsartan and sacubitril and is currently the only one on the market. Its efficacy has been shown in a large randomised trial in 2014, and LCZ696 is now part of the last 2016 European Society of Cardiology guidelines for the management of heart failure.
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