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Updated: Feb 26, 2026

Ole Isacson: Development of New Therapies for Parkinson's Disease

Ole Isacson: Development of New Therapies for Parkinson's Disease

Published on: April 29, 2007

A Serendipitous Scientist.

Robert J Lefkowitz¹

¹Howard Hughes Medical Institute, Departments of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA;

Annual Review of Pharmacology and Toxicology

|July 19, 2017

Summary

This summary is machine-generated.

A physician

Keywords:

G protein GPCR HHMI Nobel Prize autobiography lineages mentoring

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Area of Science:

Biochemistry
Molecular Biology
Medical Research

Background:

The author's early career goal was to become a physician.
Residency training was interrupted by the 1968 Doctor Draft.
Service in the US Public Health Service at the National Institutes of Health altered career path.

Purpose of the Study:

To describe the transition from physician to physician-scientist.
To recount 50 years of research on cellular receptors.
To share reflections on scientific careers, including Nobel prizes, mentoring, and funding.

Main Methods:

Personal narrative and career reflection.
Longitudinal account of research contributions.
Discussion of broader scientific and career development topics.

Main Results:

Successful transition to a physician-scientist career.
Extensive work on cellular receptors over five decades.
Insights into various aspects of scientific endeavors.

Conclusions:

The National Institutes of Health experience was pivotal.
A fulfilling career as a physician-scientist was established.
Reflections offer guidance for future scientists and insights into the scientific community.