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Single-Subject Studies in Translational Nutrition Research
Nicholas J Schork1,2,3, Laura H Goetz2,4,5
1Translational Genomics Research Institute, Phoenix, Arizona 85004;
Annual Review of Nutrition
|July 19, 2017
Summary
N-of-1 trials offer a robust method for evaluating personalized nutrition strategies by integrating complex biomedical data. These trials are crucial for validating individualized dietary interventions and health-risk mitigation approaches.
Area of Science:
- Nutritional Science
- Biomedical Research
- Translational Medicine
Background:
- Growing interest in personalized interventions for disease prevention.
- Technological advances enable detailed individual profiling (genetic, biochemical, physiological).
- Need for objective validation of personalized nutrition strategies.
Purpose of the Study:
- Review the motivation, design, and implementation of N-of-1 trials in translational nutrition.
- Assess the utility of personalized nutritional strategies.
- Explore integration of biomarker assays and clinical endpoints.
Main Methods:
- Focus on single-subject or N-of-1 trial designs.
- Discuss novel study designs and data analytical methods.
- Consider integrated use of contemporary biomedical assays and technologies.
Main Results:
- N-of-1 trials accommodate complex, integrated biomedical data.
- Example studies demonstrate the application of N-of-1 trials.
- Analytical methods for complex data generated by these trials are discussed.
Conclusions:
- N-of-1 trials are suitable for assessing personalized nutrition.
- Integration of biomarker assays and clinical endpoints enhances trial utility.
- Further research needed on algorithms for matching nutritional needs and study limitations.
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