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A Novel Pathogen Capturing Device for Removal and Detection.

Gwangseong Kim^1,2, Horatiu Vinerean³, Angelo Gaitas^4,5

¹Kytaro, Inc., Miami, FL, 33199, USA.

Scientific Reports

|July 19, 2017

Summary

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A novel antibody-coated tube effectively captures bloodborne and foodborne pathogens, concentrating them for faster diagnostics. This method significantly reduces bacterial load in blood samples and live infections, offering an economical solution for microbiology.

Area of Science:

Microbiology
Biotechnology
Medical Diagnostics

Background:

Traditional microbiology techniques often rely on enrichment, which can be time-consuming.
Accurate and rapid detection of pathogens is crucial for both clinical diagnostics and food safety.

Purpose of the Study:

To develop a simple, economical, and effective method for capturing and concentrating pathogens from biological and food samples.
To expedite diagnostic processes by reducing the time required for pathogen detection.

Main Methods:

Utilizing a polydimethylsiloxane tube coated with specific antibodies to capture target pathogens.
Recirculating entire blood or broth samples through the coated tube to achieve pathogen accumulation.
Testing the method's efficacy on Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus in blood, and Salmonella typhimurium in broth and food matrices.

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Main Results:

Successfully removed 80.3% of S. aureus and 95.4% of MRSA from blood samples within hours.
Demonstrated a two-log reduction in bacterial load in rats with induced S. aureus bloodstream infections.
Captured low concentrations of Salmonella typhimurium from large volumes of broth and detected it in ground meat samples.

Conclusions:

The antibody-coated tube technique offers an effective and economical approach for pathogen concentration and capture.
This method has significant potential for expediting microbiological diagnostics and ensuring food safety.
The technique is versatile, applicable to both bloodborne and foodborne pathogens in various sample types.