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Related Experiment Video

Updated: Feb 26, 2026

Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
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In-vivo digital wavefront sensing using swept source OCT.

Abhishek Kumar1, Lara M Wurster1, Matthias Salas1,2

  • 1Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, Währinger Gürtel 18-20 A-1090 Vienna, Austria.

Biomedical Optics Express
|July 19, 2017
PubMed
Summary
This summary is machine-generated.

Digital adaptive optics in optical coherence tomography (OCT) systems improve imaging. This study demonstrates sub-aperture digital adaptive optics for in-vivo aberration correction in retinal OCT, enhancing image quality.

Keywords:
(010.7350) Wave-front sensing(110.1080) Active or adaptive optics(110.4500) Optical coherence tomography(170.0180) Microscopy

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Area of Science:

  • Biomedical Optics
  • Optical Coherence Tomography (OCT)
  • Adaptive Optics (AO)

Background:

  • Optical aberrations limit the resolution and clarity of OCT imaging, particularly in vivo.
  • Traditional adaptive optics systems can be complex and may not be easily integrated into fiber-based OCT setups.
  • Developing efficient methods for aberration correction is crucial for advancing OCT applications in ophthalmology and other fields.

Purpose of the Study:

  • To demonstrate sub-aperture based digital adaptive optics (DAO) in a fiber-based point scanning optical coherence tomography (PS-OCT) system.
  • To utilize an in-vivo guide star approach for detecting and correcting optical aberrations in real-time.
  • To evaluate the performance of the DAO system using both phantom and human retinal OCT data.

Main Methods:

  • Implementation of a sub-aperture based digital adaptive optics system within a 1060 nm swept-source fiber-based PS-OCT.
  • Utilizing a small lateral field of view scanned at a high volume rate (17 Hz) as an in-vivo guide star to capture aberration information.
  • Quantification of root mean square wavefront error (RMS WFE) using a micro-beads phantom and human retinal OCT scans.
  • Comparison of experimental results with a Shack-Hartmann wavefront sensor where feasible.

Main Results:

  • Successful demonstration of sub-aperture DAO in the fiber-based PS-OCT system.
  • Detection of significant RMS WFE (1.48 waves) in a micro-beads phantom sample.
  • Measurement of in-vivo aberrations in human retinal OCT with an RMS WFE of 0.33 waves, exceeding the Marechal criterion for diffraction-limited performance.

Conclusions:

  • Sub-aperture based digital adaptive optics is a viable technique for correcting optical aberrations in fiber-based OCT systems.
  • The in-vivo guide star approach effectively enables real-time aberration detection and correction for improved retinal OCT imaging.
  • This technology holds promise for enhancing the diagnostic capabilities of OCT in clinical applications.