Related Experiment Video
Updated: Aug 15, 2026

15:27
Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
Dupuytren's contracture and alcohol
Annals of the Rheumatic Diseases
|April 1, 1986
Summary
Heavy alcohol consumption is strongly linked to Dupuytren
Area of Science:
- Orthopedics
- Addiction Medicine
- Clinical Biochemistry
Background:
- Dupuytren's contracture (DC) is a hand deformity with unknown etiology.
- Alcohol consumption is a potential environmental factor influencing DC development.
- Hematological markers may indicate heavy alcohol use.
Purpose of the Study:
- To investigate the association between alcohol consumption and Dupuytren's contracture.
- To compare alcohol intake in DC patients versus controls.
- To explore correlations between alcohol consumption and specific biomarkers.
Main Methods:
- A validated questionnaire assessed alcohol consumption in 64 DC patients and 89 controls.
- Serum urate (SUA), gamma-glutamyl transferase (GGT), and mean red cell volume (MCV) were measured.
- Statistical analysis compared consumption and biomarker levels between groups.
Main Results:
- Men with DC reported significantly higher daily alcohol intake (≥40g) than male controls (p=0.0001).
- Women with DC also showed higher daily alcohol intake (p=0.03).
- Elevated MCV was observed in men with DC compared to controls (p<0.0005).
- Alcohol consumption scores correlated with SUA, MCV, and GGT in DC patients.
Conclusions:
- Heavy drinking is strongly associated with Dupuytren's contracture in men.
- Hematological data (MCV) supports the self-reported heavy alcohol consumption in DC patients.
- Further research is warranted to elucidate the role of alcohol in DC pathogenesis.
Related Concept Videos
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Healing II: Complications
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Cirrhosis I: Introduction
Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

