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Published on: May 28, 2019
Reduction Of St Segment Elevation In Diabetic Patients With Myocardial Infarction After Thrombolytic Therapy
1Department of Endocrinology, Services Hospital Lahore, Pakistan.
Insights
Streptokinase (SK) effectively reduced ST-segment elevation in nearly half of acute myocardial infarction (MI) patients with diabetes. This thrombolytic therapy shows promise for managing MI in this high-risk population.
Area of Science:
- Cardiology
- Diabetology
- Pharmacology
Background:
- Acute coronary artery disease (CAD) is a leading global cause of mortality.
- Diabetic patients exhibit a higher incidence of myocardial infarction (MI).
- Streptokinase (SK) is a commonly utilized thrombolytic agent for MI resolution.
Purpose of the Study:
- To evaluate the efficacy of streptokinase (SK) in reducing ST-segment elevation.
- To assess the effectiveness of thrombolytic therapy in acute myocardial infarction (MI) patients with diabetes.
Main Methods:
- A descriptive case series of 130 patients diagnosed with acute MI.
- Patients received 1.5 MU of streptokinase (SK) intravenously.
- Electrocardiograms (ECGs) were performed pre- and post-SK administration to measure ST-segment elevation reduction.
Main Results:
- The mean age of participants was 54.42 ± 8.80 years, with 62.31% males.
- The average reduction in ST-segment elevation was 58.53 ± 26.01.
- Therapeutic efficacy, indicated by ST-segment elevation reduction, was observed in 47.7% of patients.
Conclusions:
- Streptokinase (SK) demonstrates effectiveness in approximately 47.7% of diabetic patients experiencing myocardial infarction (MI).
- Thrombolytic therapy with SK can be a viable treatment option for acute MI in diabetic individuals.
Background:
Acute coronary artery disease (CAD) is one of the main causes of death in today's world. Myocardial infarction (MI) tends to be more common among diabetic patients. One of the most effective and used (in our settings) methods of resolution of MI is administration of streptokinase (SK). This study was conducted with the aim to determine the efficacy of thrombolytic therapy in reduction of ST segment elevation in acute MI patients presenting with diabetes.
Methods:
A descriptive case series with selection of 130 patients through nonprobability purposive sampling was conducted at the Medical Departments of Services Hospital Lahore. The study was completed in 6 Months. Patients 18-80 years of age having either gender diagnosed with confirmed acute myocardial infarction were included in this study. All patients were then injected with streptokinase 1.5 mu. Pre S and Post SK ECGs were done and ST segment elevation measured also measuring reduction of ST segment.
Results:
The mean age of the patients was noted as 54.42±8.80 years. There were 62.31% males. Mean reduction in ST-segment elevation of the patients was noted as 58.53±26.01. The efficacy was achieved in 47.7% patients.
Conclusions:
It is concluded that SK can be effective in almost half of diabetic patients with myocardial infarction.
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