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Iron Deficiency Anaemia As Risk Factor For Simple Febrile Seizures: A Case Control Study

Khawaja Tahir Aziz1, Naheem Ahmed1, Abdul Ghaffar Nagi1

  • 1Department of Paediatrics, AJK Medical College/Shaikh Khalifa Bin Zayed Al-Nahyan Hospital/CMH, Muzaffarabad-Azad Jammu & Kashmir, Pakistan.

Journal of Ayub Medical College, Abbottabad : JAMC
|July 19, 2017
PubMed

Insights

Iron deficiency anemia significantly increases the risk of febrile seizures in children. Preventing and treating iron deficiency anemia can help reduce the occurrence of these seizures.

Area of Science:

  • Pediatrics
  • Hematology
  • Neurology

Background:

  • Febrile seizures are a common pediatric concern.
  • Iron deficiency anemia (IDA) is a preventable and treatable condition.
  • IDA is hypothesized to be an aggravating factor for febrile seizures.

Purpose of the Study:

  • To investigate iron deficiency anemia as a risk factor for febrile seizures in children.

Main Methods:

  • A case-control study was conducted with 30 children experiencing febrile seizures (cases) and 30 age- and variable-matched children without febrile seizures (controls).
  • Hematological parameters including hemoglobin, hematocrit, MCV, MCH, MCHC, RBC, and RDW were analyzed.
  • Statistical analysis was performed using SPSS version 20.0.

Main Results:

  • A higher prevalence of hemoglobin levels below 11.0 gm% was observed in the febrile seizure group (21 cases) compared to the control group (13 cases).
  • The odds ratio for febrile seizures associated with low hemoglobin was 3.05 (95% CI: 1.05-8.84).
  • Statistically significant differences (p<0.05) were found in mean hematocrit, RBC, MCV, MCH, MCHC, and RDW between the case and control groups.

Conclusions:

  • Iron deficiency anemia is identified as a significant risk factor for febrile seizures.
  • Effective prevention and treatment strategies for IDA may lead to a decreased incidence of febrile seizures in children.
Abstract

Keywords:
AnaemiaChildrenFebrile fitsFits

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