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Related Experiment Videos

Repeat chemonucleolysis.

J C Sutton

    Clinical Orthopaedics and Related Research
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Repeat chemonucleolysis offers a 73% success rate for recurrent lumbar disc herniations. Pretreatment with histamine blockers effectively minimizes anaphylaxis risk, making it a viable alternative to surgery.

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    Area of Science:

    • Neurosurgery
    • Minimally Invasive Procedures
    • Pharmacology

    Background:

    • Recurrent lumbar disc herniations present a challenge for conservative treatment.
    • Repeat chemonucleolysis is an alternative to surgical interventions like laminectomy and discectomy.
    • Anaphylaxis is a potential risk associated with chymopapain enzyme used in chemonucleolysis.

    Purpose of the Study:

    • To evaluate the efficacy and safety of repeat chemonucleolysis for recurrent lumbar disc herniations.
    • To assess the effectiveness of histamine antagonists in preventing anaphylactic reactions during repeat chemonucleolysis.

    Main Methods:

    • A retrospective review of 33 patients undergoing repeat chemonucleolysis between 1979 and 1983.
    • Analysis of success rates and immediate sensitivity reactions (anaphylaxis).

    Related Experiment Videos

  • Comparison of outcomes in patients pretreated with histamine1 and histamine2 antagonists versus those without pretreatment.

    • Main Results:

    • Repeat chemonucleolysis achieved satisfactory results in 73% of patients (24 out of 33).
    • Three patients experienced anaphylaxis, all successfully managed.
    • No anaphylactic reactions occurred in the 12 patients pretreated with histamine1 and histamine2 antagonists.

    Conclusions:

    • Repeat chemonucleolysis is a viable and effective treatment for recurrent lumbar disc herniations refractory to conservative therapy.
    • Pretreatment with histamine blockers significantly reduces the risk of anaphylaxis, enhancing the safety profile of repeat chemonucleolysis.
    • This approach offers a valuable alternative to laminectomy and discectomy, improving patient outcomes.