Related Experiment Video
Updated: Feb 26, 2026
Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
Published on: January 15, 2017
Thrombotic Microangiopathy: A Multidisciplinary Team Approach
Craig E Gordon1, Vipul C Chitalia1, J Mark Sloan2
1Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA.
Abstract:
Thrombotic microangiopathy (TMA) is characterized by the presence of microangiopathic hemolytic anemia and thrombocytopenia along with organ dysfunction, and pathologically, by the presence of microthrombi in multiple microvascular beds. Delays in diagnosis and initiation of therapy are common due to the low incidence, variable presentation, and poor awareness of these diseases, underscoring the need for interdisciplinary approaches to clinical care for TMA. We describe a new approach to improve clinical management via a TMA team that originally stemmed from an Affinity Research Collaborative team focused on thrombosis and hemostasis. The TMA team consists of clinical faculty from different disciplines who together are charged with the responsibility to quickly analyze clinical presentations, guide laboratory testing, and streamline prompt institution of treatment. The TMA team also includes faculty members from a broad range of disciplines collaborating to elucidate the pathogenesis of TMA. To this end, a clinical database and biorepository have been constructed. TMA leaders educate front-line providers from other departments through presentations in various forums across multiple specialties. Facilitated by an Affinity Research Collaborative mechanism, we describe an interdisciplinary team dedicated to improving both clinical care and translational research in TMA.
Insights
A new interdisciplinary Thrombotic Microangiopathy (TMA) team improves patient care by streamlining diagnosis and treatment. This collaborative approach also advances research into the causes of TMA, enhancing overall management strategies.
Area of Science:
- Hematology
- Clinical Medicine
- Translational Research
Background:
- Thrombotic microangiopathy (TMA) presents with microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction.
- Delayed diagnosis and treatment initiation are common due to TMA's rarity and varied presentation.
- Interdisciplinary collaboration is crucial for effective TMA management.
Purpose of the Study:
- To describe a novel interdisciplinary team approach for improving clinical management of TMA.
- To establish a collaborative framework for advancing translational research in TMA.
- To enhance awareness and education of front-line providers regarding TMA.
Main Methods:
- Formation of a dedicated TMA team with faculty from diverse clinical disciplines.
- Development of a clinical database and biorepository for TMA research.
- Educational outreach to front-line providers across various specialties.
Main Results:
- The TMA team facilitates rapid clinical assessment, laboratory guidance, and prompt treatment initiation.
- The established infrastructure supports collaborative efforts to understand TMA pathogenesis.
- Educational initiatives aim to improve early recognition and management by a wider range of clinicians.
Conclusions:
- An interdisciplinary TMA team, supported by research infrastructure, can significantly improve clinical care.
- This collaborative model enhances both patient management and the understanding of TMA.
- Effective communication and education are key to optimizing TMA treatment and research outcomes.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
01:29Therapeutic Drug Monitoring: Affecting Factors
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
01:27Peripheral Artery Disease III: Interprofessional Care
01:16Therapeutic Drug Monitoring: Overview and Classification
01:30Venous Thrombosis IV: Nursing Management