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Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Alexandra Iulia Irimie1, Laura Sonea2, Ancuta Jurj3

  • 1Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine.

International Journal of Nanomedicine
|July 20, 2017
PubMed

Insights

Nanotechnology offers a promising alternative for oral cancer treatment, enhancing efficiency and reducing toxicity compared to traditional methods. Nanosystems show potential for clinical application, with ongoing trials exploring their therapeutic benefits.

Area of Science:

  • Oncology
  • Nanomedicine
  • Biotechnology

Background:

  • Oral cancer presents significant global health challenges.
  • Traditional treatments for oral cancer have limitations and side effects.
  • Nanotechnology offers novel therapeutic and prognostic strategies for oral cancer.

Purpose of the Study:

  • To review the benefits and challenges of nanosystems in oral cancer therapy.
  • To explore various nanosystems developed for oral cancer treatment.
  • To assess the clinical potential of nanotechnology in managing oral cancer.

Main Methods:

  • Review of existing literature on nanosystems for oral cancer.
  • Analysis of different types of nanosystems (polymeric, metallic, lipid-based).
  • Examination of incorporated therapeutic agents (chemotherapeutics, natural compounds, siRNA).

Main Results:

  • Nanosystems demonstrate enhanced efficiency and reduced toxicity in preclinical studies.
  • Various formulations show potential for targeted drug delivery in oral cancer.
  • Few nanosystems have progressed to clinical trials, despite promising in vitro and in vivo results.

Conclusions:

  • Nanosystems represent a potential breakthrough in oral cancer treatment.
  • Further clinical trials are needed to validate the efficacy and safety of these nanotherapies.
  • Nanotechnology holds promise as a future therapeutic option for oral cancer patients.
Keywords:
dendrimerslipidic nanosystemsnanoparticleoral cancerpolymeric micelles

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