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Changes within the genus Bordetella influenced by phages.

S Mebel, I A Lapaeva, L N Sinyashina

    Developments in Biological Standardization
    |January 1, 1985
    PubMed
    Summary

    Bordetella phages alter Bordetella species

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    Area of Science:

    • Microbiology
    • Bacteriology
    • Virology

    Background:

    • Bordetella species are significant human and animal pathogens.
    • Bordetella phages are known to influence bacterial characteristics.
    • Understanding phage-host interactions is crucial for controlling Bordetella infections.

    Purpose of the Study:

    • To investigate the phenotypic and pathogenic changes in Bordetella species induced by Bordetella pertussis phages.
    • To characterize the properties of phage-converted Bordetella strains.

    Main Methods:

    • Treatment of Bordetella parapertussis with B. pertussis phages.
    • Phenotypic analysis of converted strains, including agglutinogen profiles, phage sensitivity, and antibiotic tolerance.
    • Assessment of pathogenicity in mouse models, evaluating brain tissue propagation and clinical signs.
    • Detection of adhesive and hemagglutinating activities.
    • Comparison of converted strains with wild-type B. bronchiseptica.

    Main Results:

    • Phage treatment induced toxic Bordetella clones with altered agglutinogen combinations.
    • Converted strains exhibited changes in phage sensitivity, antibiotic tolerance (erythromycin resistance as a marker), adhesion, and hemagglutination.
    • Converted strains showed increased virulence, propagating in mouse brain tissue and causing paralysis or death.
    • Converted strains resembled wild B. bronchiseptica strains.

    Conclusions:

    • Bordetella phages can significantly alter the phenotypic and pathogenic properties of Bordetella species.
    • Phage conversion can lead to enhanced virulence and altered characteristics, mimicking wild-type strains.
    • Erythromycin tolerance serves as a reliable marker for phage conversion in Bordetella.

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