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Updated: Feb 26, 2026

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A glimpse at the aging eye.

Jonathan B Lin1,2, Kazuo Tsubota3, Rajendra S Apte1,2,4,5

  • 1Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO, USA.

NPJ Aging and Mechanisms of Disease
|July 20, 2017
PubMed
Summary
This summary is machine-generated.

Organismal aging impairs eye function, leading to vision loss and disease. Understanding the cellular basis of aging eyes is crucial for developing new therapies to improve vision and combat age-related eye conditions.

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Cellular Biology

Background:

  • Aging is linked to tissue dysfunction across organs, including the eye.
  • The eye's complex structures, like the cornea, lens, and retina, are vital for vision and susceptible to age-related changes.
  • Age-associated visual impairment has significant psychosocial impacts, yet effective treatments remain limited.

Purpose of the Study:

  • To review the cellular and molecular pathophysiology of the aging eye.
  • To highlight the need for improved therapeutic strategies for age-related visual decline.
  • To provide a foundation for developing targeted therapies against cellular aging in the eye.

Main Methods:

  • This review synthesizes existing research on the aging eye.
  • It focuses on cellular and molecular mechanisms underlying age-related ocular dysfunction.
  • The review examines how aging impacts ocular tissues and leads to disease.

Main Results:

  • Aging significantly affects ocular structures, leading to well-defined clinical conditions.
  • Ocular tissue dysfunction and disease are common consequences of the aging process.
  • Current treatments for many age-related eye conditions are insufficient.

Conclusions:

  • A deeper understanding of the aging eye's pathophysiology is essential.
  • Targeted therapies aimed at cellular aging could mitigate age-related vision loss.
  • Further research is needed to develop strategies to decelerate or reverse age-associated ocular deterioration.