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Multispectral fluorescence guided surgery; a feasibility study in a phantom using a clinical-grade laparoscopic
Danny M van Willigen1, Nynke S van den Berg1,2, Tessa Buckle1
1Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical CenterAlbinusdreef 2, 2300 RC, Leiden, The Netherlands.
Summary
This study demonstrates a new multispectral fluorescence laparoscope for improved surgical precision. The system enhances visualization of diseased versus healthy tissue, aiding complex procedures like nerve sparing prostatectomy.
Area of Science:
- Surgical Technology
- Medical Imaging
- Oncology
Background:
- Image-guided surgery advancements are rapid, yet precision in differentiating diseased from delicate structures remains a challenge in complex procedures like nerve sparing prostatectomy.
- Accurate tissue differentiation is crucial for improving surgical outcomes and minimizing complications.
Purpose of the Study:
- To provide proof of concept for a modified clinical-grade fluorescence laparoscope system.
- To evaluate the system's capability in detecting white light and multiple fluorescent dyes sequentially.
- To assess the potential of laparoscopic multispectral imaging for enhanced tissue differentiation in prostate cancer surgery.
Main Methods:
- A modified clinical-grade fluorescence laparoscope was developed and tested.
- The system was analyzed for its properties and detection capabilities.
- Sequential detection of white light, fluorescein, Cy5, and indocyanine green (ICG) was performed.
- Laparoscopic three-color multispectral imaging was demonstrated in a prostate cancer phantom setup.
Main Results:
- The fluorescence laparoscope system demonstrated sensitive detection of white light and three fluorescent dyes (fluorescein, Cy5, ICG) sequentially.
- Detailed analysis confirmed the system's properties and detection capabilities.
- The potential for laparoscopic three-color multispectral imaging combined with white light imaging was shown in a phantom model.
Conclusions:
- A modified fluorescence laparoscope system shows promise for enhancing surgical precision.
- Multispectral fluorescence imaging can aid in differentiating between healthy and diseased tissue during complex surgeries.
- This technology has potential applications in improving nerve sparing prostatectomy and other oncological procedures.
