Multifunctional nanoparticles as a tissue adhesive and an injectable marker for image-guided procedures

Area of Science:

• Biomaterials Science
• Nanotechnology
• Surgical Innovation

Background:

• Tissue adhesives are emerging as alternatives to sutures and staples for wound closure.
• Minimally invasive procedures increasingly utilize tissue adhesives for convenience and effectiveness.
• Current tissue adhesives often lack sufficient imaging detectability and biocompatibility for intracorporeal use.

Purpose of the Study:

• To develop and evaluate biocompatible core/shell nanoparticles as advanced tissue adhesives.
• To assess the imaging capabilities and adhesive properties of these novel nanoparticles.
• To compare the biocompatibility and inflammatory response of the new adhesive with a clinically used alternative.

Main Methods:

• Synthesis of tantalum oxide/silica core/shell nanoparticles (TSNs).
• Evaluation of imaging contrast effects using clinical imaging modalities.
• Assessment of adhesive strength and biocompatibility through in vitro and in vivo studies.
• Comparison of cellular toxicity and inflammatory markers against a cyanoacrylate-based adhesive.

Main Results:

• TSNs demonstrated high contrast for real-time imaging and strong adhesive properties.
• Biocompatible TSNs exhibited significantly less cellular toxicity and inflammation compared to a clinical tissue adhesive.
• Successful application of TSNs as a hemostatic adhesive in minimally invasive procedures.
• Demonstrated utility of TSNs as an immobilized marker for image-guided interventions.

Conclusions:

• Biocompatible tantalum oxide/silica core/shell nanoparticles offer a multifunctional solution for tissue adhesion and imaging.
• TSNs present a safer and more effective alternative to existing imageable tissue adhesives.
• These nanoparticles hold significant potential for advancing minimally invasive surgery and image-guided procedures.