Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.3K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

2.2K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.2K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

278
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
278
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

321
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
321
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

283
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
283
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

761
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
761

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolated aortic valve-sparing aortic root replacement in elective patients with bicuspid aortic valve: A single-center experience.

JTCVS open·2026
Same author

Long-Term Results After Senning and Mustard Operations for d-Transposition of the Great Arteries: Atrial Switch Should Remain in Armamentarium.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2026
Same author

[Core curriculum of intensive care and emergency medicine in internal medicine].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2025
Same author

Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis.

Circulation·2025
Same author

Exercise Performance and Right Ventricular Remodeling After the Cone Repair in Patients With Different Severity of Ebstein Anomaly.

The Annals of thoracic surgery·2025
Same author

Technical implications of a novel deep learning system in the segmentation and evaluation of computed tomography angiography before transcatheter aortic valve replacement.

Therapeutic advances in cardiovascular disease·2025

Related Experiment Video

Updated: Feb 26, 2026

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
09:19

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Published on: December 9, 2014

26.4K

[Parkinson's disease in the elderly].

Rüdiger Lange1, Frank Erbguth2

  • 1Klinikum Nürnberg Süd, Paracelsus Medizinische Privatuniversität, Breslauer Str. 201, 90471, Nürnberg, Deutschland. ruediger.lange@klinikum-nuernberg.de.

Zeitschrift Fur Gerontologie Und Geriatrie
|July 21, 2017
PubMed
Summary

The number of elderly patients with idiopathic Parkinson's disease (PD) is rising, necessitating tailored therapeutic strategies. Addressing both motor and non-motor symptoms is crucial for improving their quality of life.

Keywords:
AgedLevodopaMobilityParkinson DiseasePolypharmacy

More Related Videos

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.6K
Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

8.4K

Related Experiment Videos

Last Updated: Feb 26, 2026

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults
09:19

Community-based Adapted Tango Dancing for Individuals with Parkinson's Disease and Older Adults

Published on: December 9, 2014

26.4K
Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
07:21

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease

Published on: June 16, 2023

1.6K
Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

8.4K

Area of Science:

  • Geriatric Medicine
  • Neurology
  • Pharmacology

Background:

  • Increasing life expectancy leads to a higher incidence of idiopathic Parkinson's disease (PD) in the elderly population.
  • Elderly patients face a greater burden of comorbidities and are more susceptible to medication side effects, especially with polypharmacy.

Purpose of the Study:

  • To highlight the growing need for increased awareness and therapeutic knowledge regarding Parkinson's disease management in the elderly.
  • To emphasize the importance of addressing both motor and non-motor symptoms in this demographic.

Main Methods:

  • Review of current literature on Parkinson's disease in elderly patients.
  • Analysis of challenges associated with comorbidities and polypharmacy.
  • Consideration of non-pharmacological interventions and supportive care.

Main Results:

  • Idiopathic Parkinson's disease (PD) management in the elderly requires a comprehensive approach beyond motor symptom treatment.
  • Non-motor symptoms, including neuropsychiatric and autonomic disorders, significantly impact quality of life and require dedicated management.
  • Non-pharmacological treatments, medical aids, and caregiving become increasingly vital in advanced stages.

Conclusions:

  • A heightened level of awareness and specialized therapeutic knowledge is essential for effectively managing Parkinson's disease in the aging population.
  • Integrated care addressing motor, non-motor symptoms, and psychosocial support is critical for enhancing the quality of life for elderly Parkinson's patients.