Population specific analysis of Yakut exomes.

Area of Science:

• Population genetics
• Human genomics
• Molecular anthropology

Background:

• Understanding the genetic makeup of isolated populations is crucial for human evolutionary studies.
• The Yakut population in Siberia represents a unique demographic group with limited previous genetic research.
• Comparative genomics provides insights into population history and admixture.

Purpose of the Study:

• To investigate the genetic diversity and structure of the Yakut population.
• To identify Yakut-specific genetic variations (alleles).
• To compare the Yakut genetic profile with global populations.

Main Methods:

• Exome sequencing was employed to capture coding regions of the genome.
• Comparative analysis was conducted with populations from the 1000 Genomes Project.
• Bioinformatic tools were used for variant calling and population structure analysis.

Main Results:

• Identification of genetic alleles specific to the Yakut population.
• The Yakut population forms a distinct genetic cluster.
• Yakut genetic clustering is positioned intermediate to European and East Asian populations.

Conclusions:

• The Yakut population exhibits unique genetic characteristics.
• Exome sequencing is effective for characterizing population-specific genetic diversity.
• The findings contribute to understanding Siberian population genetics and human migration patterns.