Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clipper Circuit01:18

Clipper Circuit

912
A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
912
Clamper Circuit01:14

Clamper Circuit

1.1K
A clamper circuit, also known as a DC restorer, represents a specialized variant of the rectifier circuit, notable for its method of taking the output across the diode rather than the capacitor. This configuration lends to several distinctive applications, particularly in handling square wave inputs.
Within this circuit, the diode's orientation prompts the capacitor to charge up to the level of the most negative peak of the input signal. Upon reaching this state, the diode ceases to...
1.1K
Patch Clamp01:18

Patch Clamp

6.9K
Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
6.9K
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

9.7K
Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
9.7K
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

9.5K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
9.5K
Lampbrush Chromosomes01:51

Lampbrush Chromosomes

3.0K
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tobacco smoking disrupts bile acid and tryptophan metabolism in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

A Pre-symptomatic phase of tumefactive multiple sclerosis mirrors radiologically isolated syndrome.

Multiple sclerosis and related disorders·2026
Same author

Mutational Profiling Links Biologically Relevant Variants to Multi-Systemic Rosai-Dorfman Disease.

Blood advances·2026
Same author

Associations between perfluoroalkyl substances and multiple sclerosis in U.S. cohorts compared with NMOSD, MOGAD, and healthy controls.

Environmental research·2026
Same author

Percutaneous spinal stimulation to enhance gait and alleviate functional impairments in multiple sclerosis: A pilot study.

Multiple sclerosis journal - experimental, translational and clinical·2026
Same author

Impact of modern central nervous system radiation on multiple sclerosis relapse and progression.

Clinical and translational radiation oncology·2026
Same journal

Update on Genetic Chorea.

Current neurology and neuroscience reports·2026
Same journal

Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Noradrenergic Brain in Parkinson's Disease.

Current neurology and neuroscience reports·2026
Same journal

Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.

Current neurology and neuroscience reports·2026
Same journal

Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.

Current neurology and neuroscience reports·2026
See all related articles

Related Experiment Video

Updated: Feb 26, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

15.9K

CLIPPERS.

Nicholas L Zalewski1, W Oliver Tobin2,3

  • 1Department of Neurology, Mayo Clinic, Rochester, MN, USA.

Current Neurology and Neuroscience Reports
|July 21, 2017
PubMed
Summary
This summary is machine-generated.

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare brainstem inflammation. Differentiating CLIPPERS from mimics like malignancy is crucial for accurate diagnosis and treatment.

Keywords:
Brainstem encephalitisCLIPPERSEncephalomyelitisLymphomaPCNSLVasculitis

More Related Videos

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
18:50

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment

Published on: September 25, 2009

14.1K
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

26.2K

Related Experiment Videos

Last Updated: Feb 26, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
12:00

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model

Published on: November 24, 2014

15.9K
Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment
18:50

Microsurgical Clip Obliteration of Middle Cerebral Aneurysm Using Intraoperative Flow Assessment

Published on: September 25, 2009

14.1K
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
08:38

Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

Published on: August 28, 2013

26.2K

Area of Science:

  • Neurology
  • Neuroimmunology
  • Neuroinflammation

Background:

  • Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a distinct clinicoradiographic syndrome.
  • Diagnosis is challenging due to the lack of specific biomarkers, necessitating careful evaluation for disease mimics.

Purpose of the Study:

  • To review the characteristic clinical, radiographic, and pathological features of CLIPPERS.
  • To highlight the importance of considering alternative diagnoses in non-classic presentations.
  • To provide guidance on diagnostic evaluation and initial treatment.

Main Methods:

  • Literature review of CLIPPERS and CLIPPERS-like lesions.
  • Analysis of clinical, imaging, and pathological findings.
  • Synthesis of diagnostic and therapeutic recommendations.

Main Results:

  • CLIPPERS presents as a brainstem-predominant encephalomyelitis responsive to steroids.
  • Many reported CLIPPERS-like lesions have alternative diagnoses including malignancies and vasculitis.
  • CLIPPERS may represent an initial presentation of various underlying etiologies.

Conclusions:

  • Accurate diagnosis of CLIPPERS requires distinguishing it from mimickers based on classic features.
  • A thorough diagnostic workup is essential when clinical or radiographic findings are atypical.
  • Prompt and appropriate management is guided by a confirmed or suspected CLIPPERS diagnosis.