Mycoplasma pneumoniae-associated Hepatitis without Lung Involvement.

Area of Science:

• Infectious Diseases
• Hepatology
• Pulmonology

Background:

• Mycoplasma pneumoniae is a common cause of respiratory infections.
• Extrapulmonary manifestations of Mycoplasma pneumoniae are known but typically involve cardiovascular, dermatological, musculoskeletal, and hematological systems.
• Acute hepatitis as an isolated presentation of Mycoplasma pneumoniae in adults is rare.

Observation:

• A 32-year-old male presented with fever, chills, myalgia, and headache.
• Biochemical analysis revealed severely impaired liver function and leukopenia.
• Laboratory tests and liver biopsy confirmed a hepatocellular pattern of acute hepatitis.

Findings:

• The patient was diagnosed with Mycoplasma pneumoniae-associated acute hepatitis.
• Hepatocellular injury pattern was identified.
• Rapid clinical and laboratory improvement was observed following macrolide treatment.

Implications:

• Mycoplasma pneumoniae should be considered in the differential diagnosis of acute hepatitis, particularly when lung or other extrapulmonary involvement is absent.
• Prompt diagnosis and treatment with macrolides can lead to rapid recovery.
• This case highlights the diverse clinical spectrum of Mycoplasma pneumoniae infections.