Related Experiment Video
Updated: Feb 26, 2026
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Factors associated with global longitudinal strain decline in hypertensive patients with normal left ventricular
Nabila Soufi Taleb Bendiab1,2, Abderrahim Meziane-Tani1,2, Souhila Ouabdesselam2,3
11 Department of Cardiology, Faculty of Medicine Aboubekr Belkaid University Hospital Tlemcen, Tlemcen, Algeria.
Insights
Early detection of left ventricular (LV) dysfunction in high blood pressure (HBP) patients is possible using global longitudinal strain (GLS). Reduced GLS indicates early impairment, linked to uncontrolled HBP, diabetes, and LV hypertrophy.
Area of Science:
- Cardiology
- Echocardiography
- Hypertension Research
Background:
- Early detection of left ventricular (LV) dysfunction risk factors is crucial for managing high blood pressure (HBP).
- Assessing LV global longitudinal strain (GLS) via speckle-tracking echocardiography offers a potential method for early detection.
Purpose of the Study:
- To investigate the association between reduced LV global longitudinal strain (GLS) and various risk factors in patients with high blood pressure (HBP).
- To identify predictors of impaired LV function in an HBP outpatient clinic population.
Main Methods:
- Two-dimensional Doppler-coupled echocardiography with speckle-tracking to determine LV GLS in 200 HBP patients.
- Analysis of patient demographics, comorbidities (diabetes, dyslipidemia, overweight), HBP control, LV hypertrophy (LVH), and diastolic dysfunction.
Main Results:
- Reduced GLS (>-17%) was observed in 45.5% of patients.
- Univariate analysis linked lower GLS to longer HBP duration, uncontrolled BP, overweight, diabetes, dyslipidemia, renal failure, increased Cornell index, LVH, remodeling, and filling pressures.
- Multivariable analysis confirmed associations between reduced GLS and HBP duration, uncontrolled BP, diabetes, LVH, and increased filling pressures.
Conclusions:
- Early impairment of LV function, indicated by reduced GLS, is prevalent in HBP patients.
- Reduced GLS is significantly associated with long-standing, uncontrolled HBP, metabolic changes, and LVH.
Abstract:
Background Early detection of risk factors for left ventricular (LV) dysfunction may be useful in patients with high blood pressure (HBP). Methods Patient from an outpatient HBP clinic underwent a two-dimensional Doppler-coupled echocardiography with determination of LV global longitudinal strain (GLS) by speckle-tracking. Results Among 200 patients (mean age 61.7 ± 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. LV hypertrophy (LVH) was found in 136 patients (68%), including concentric ( n = 106) and eccentric ( n = 30) LVH. Diastolic dysfunction patterns were observed in 178 patients (89%), and increased filling pressures were observed in 37 patients (18.5%). GLS ranged from -25% to -11.6% (mean -16.9 ± 3.2%). Low GLS values (>-17%) were found in 91 patients (45.5%), 68 with and 23 without LVH. In univariate analysis, a reduced GLS was associated with HBP lasting for >10 years (odds ratio (OR) = 3.51, 95% confidence interval (CI) 1.73-7.09; p = 0.002), uncontrolled HBP (OR = 3.55, 95% CI 1.96-6.43; p < 0.0001), overweight (OR = 2.01, 95% CI 0.93-4.31; p = 0.0028), diabetes (OR = 2.21, 95% CI 1.25-3.90; p = 0.006), dyslipidemia (OR = 2.16, 95% CI 1.22-3.84; p = 0.008), renal failure (OR = 4.27, 95% CI 1.80-10.10; p = 0.001), an increased Cornell index (OR = 3.70, 95% CI 1.98-6.90; p < 0.0001), concentric LVH (OR = 9.26, 95% CI 2.62-32.73; p = 0.001), remodeling (OR = 8.51, 95% CI 2.18-33.23; p = 0.002), and filling pressures (OR = 7.1, 95% CI 2.9-17.3; p < 0.0001). In multivariable analysis, duration of HBP ( p = 0.038), uncontrolled BP ( p = 0.006), diabetes ( p = 0.023), LVH ( p = 0.001), and increased filling pressures ( p = 0.003) remained associated with GLS decline. Conclusion Early impairment of LV function, detected by a reduced GLS, is associated with long-lasting, uncontrolled HBP, overweight, related metabolic changes, and is more pronounced in patients with LVH.
More Related Videos
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
04:48Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
Related Concept Videos
01:29Heart Failure II: Pathophysiology
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
01:17Pathophysiology of Heart Failure
01:28Factors affecting Blood pressure
Physiological Factors:
01:20Mitral Regurgitation I: Introduction
01:29Hypertension II: Pathophysiology