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Optimal Foraging

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How animals obtain and eat their food is called foraging behavior. Foraging can include searching for plants and hunting for prey and depends on the species and environment.

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Striatal GPR88 Modulates Foraging Efficiency.

Aundrea Rainwater¹, Elisenda Sanz², Richard D Palmiter¹

¹Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience

|July 22, 2017

Summary

This summary is machine-generated.

Mice lacking GPR88 (G-protein-coupled receptor 88) in the striatum struggle with foraging decisions. GPR88 is essential for integrating reward value and effort in action selection.

Keywords:

action selection decision making mouse genetics striatum

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Area of Science:

Neuroscience
Behavioral Neuroscience
Molecular Neuroscience

Background:

The striatum plays a key role in foraging and action selection.
GPR88 (G-protein-coupled receptor 88) is a striatal-enriched receptor influencing neuron excitability.
Efficient foraging requires integrating caloric value and effort.

Purpose of the Study:

To investigate the role of GPR88 in instrumental choice behavior related to foraging.
To determine if GPR88 is necessary for evaluating reward quantity and effort.

Main Methods:

Studied instrumental choice behavior in mice lacking GPR88 (KO mice) and wild-type (WT) controls.
Utilized lever press tasks with varying reward quantities and effort requirements.
Restored GPR88 expression in the striatum of KO mice to assess rescue effects.

Main Results:

KO mice showed delayed acquisition of food-reinforced lever pressing.
KO mice failed to discriminate between different reward quantities or effort levels.
Restoring GPR88 in the striatum rescued the preference for higher-reward levers.

Conclusions:

Striatal GPR88 expression is crucial for efficient action selection during foraging.
GPR88 integrates information about reward value and effort to guide behavior.
Dysfunction in GPR88 may contribute to striatal deficits observed in certain neurological conditions.