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Published on: September 3, 2010
A layer-by-layer assembled MoS2 thin film as an efficient platform for laser desorption/ionization mass spectrometry
Young-Kwan Kim1, Li-Sheng Wang, Ryan Landis
1Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Abstract:
A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure.
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