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Updated: Feb 26, 2026

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
Role of Mesenchymal Stem Cells in Cancer Development and Their Use in Cancer Therapy
Nedime Serakinci1,2, Pinar Tulay3, Rasime Kalkan3
1Faculty of Medicine, Department of Medical Genetics, Near East University, Nicosia, Cyprus. nedimeserakinci@gmail.com.
Abstract:
Stem cells have the ability to perpetuate themselves through self-renewal and generate mature cells of a particular tissue through differentiation. Mesenchymal stem cells (MSCs) play an important role in tissue homeostasis - supporting tissue regeneration. MSCs are rare pluripotent cells supporting hematopoietic and mesenchymal cell lineages. MSCs have a great therapeutic potential in cancer therapy, as well as stem cell exosome and/or microvesicle-mediated tissue regeneration. In this review, the use of hMSCs in stem cell-mediated cancer therapy is discussed.
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