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Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
Published on: May 25, 2018
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Fostering responsible research with genome editing technologies: a European perspective
Hervé Chneiweiss1, François Hirsch2, Lluis Montoliu3
1INSERM Ethics Committee, Paris, France. Herve.chneiweiss@inserm.fr.
Transgenic Research
|July 22, 2017
Summary
European experts propose a new steering committee to evaluate genome editing technologies, addressing benefits, risks like off-targets, and societal impacts for responsible implementation and legislation.
Area of Science:
- Genetics
- Biotechnology
- Bioethics
Background:
- A consensus meeting involving over 20 European partners convened to discuss genome editing technologies.
- The need for a structured approach to assess the implications of advanced genetic tools was identified.
Discussion:
- The formation of a European Steering Committee is recommended to evaluate genome editing.
- This committee will analyze potential benefits and drawbacks, including technical challenges like off-target effects and mosaicism.
- Developing risk matrices and scenarios for responsible technology deployment is a key objective.
Key Insights:
- A proactive, expert-led assessment is crucial for the responsible advancement of genome editing.
- Addressing both technical and societal dimensions is essential for public trust and regulatory frameworks.
Outlook:
- The steering committee will foster open societal debate on genome editing.
- Recommendations will inform national and international legislation for ethical and safe application of genome editing.
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