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Total Syntheses of Cystobactamids and Structural Confirmation of Cystobactamid 919-2
Bichu Cheng1,2, Rolf Müller3, Dirk Trauner1,2
1Department of Chemistry, University of Munich, Butenandtstrasse 5-13, Haus F, 81377, Munich, Germany.
Angewandte Chemie (International Ed. in English)
|July 22, 2017
Abstract:
The cystobactamids are a family of antibacterial natural products with unprecedented chemical scaffolds that are active against both Gram-positive and Gram-negative pathogens. Herein, we describe the first total synthesis of cystobactamid 919-2 from three fragments. Our convergent synthesis enabled both the confirmation of the correct structure and the determination of the absolute configuration of cystobactamid 919-2.

