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Updated: Feb 26, 2026

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

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Published on: January 10, 2017

Interaction between cavitation microbubble and cell: A simulation of sonoporation using boundary element method

Xiasheng Guo¹, Chenliang Cai¹, Guangyao Xu¹

¹Key Laboratory of Modern Acoustics (MOE), Department of Physics, Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, China.

Ultrasonics Sonochemistry

|July 23, 2017

Summary

This study developed a 2D boundary element method model to understand microbubble-cell interactions during sonoporation. The model helps optimize ultrasound parameters for safer and more efficient gene delivery in clinical applications.

Keywords:

Boundary element method Inertial cavitation Microbubble Sonoporation

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Area of Science:

Biophysics
Biomedical Engineering
Acoustic Medicine

Background:

Sonoporation is a key technique for gene delivery and causes bio-effects like hemolysis.
Understanding the mechanism of microbubble-cell interaction is crucial for optimizing sonoporation.
Existing models require further development to capture detailed cell membrane dynamics.

Purpose of the Study:

To develop a 2D boundary element method (BEM) model for investigating microbubble-cell interactions.
To analyze the morphological and mechanical characteristics of cell membranes during sonoporation.
To provide insights for enhancing the safety and efficiency of sonoporation techniques.

Main Methods:

A two-dimensional boundary element method (BEM) model was employed.
The model simulated microbubble-cell interactions, focusing on the cell membrane's close-to-bubble point (CP).
Time evolution analysis of sonoporation was performed, extracting parameters like bubble volume, cell area expansion, jet velocity, and CP displacement.

Main Results:

The model successfully simulated microbubble-cell interactions and sonoporation dynamics.
Parametric studies revealed the influence of ultrasound parameters (frequency, pressure) and geometry (bubble-cell distance, bubble radius).
Detailed information on cell membrane deformation and bubble behavior was extracted for analysis.

Conclusions:

The developed 2D BEM model is a powerful tool for understanding bubble-cell interactions.
The findings can guide the optimization of sonoporation strategies for improved safety and efficiency.
This research supports the advancement of sonoporation in biological and clinical applications.