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A Role for the Left Angular Gyrus in Episodic Simulation and Memory.

Preston P Thakral1, Kevin P Madore2, Daniel L Schacter2

  • 1Department of Psychology, Harvard University, Boston, Massachusetts 02138 prestonthakral@fas.harvard.edu.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|July 23, 2017
PubMed
Summary
This summary is machine-generated.

Transcranial magnetic stimulation (TMS) revealed the left angular gyrus is crucial for imagining future experiences (episodic simulation) and recalling past events (episodic memory). Disrupting this brain region impaired detailed recall and increased irrelevant information.

Keywords:
TMSangular gyrusepisodic memoryepisodic simulationfMRIparietal cortex

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Episodic simulation and memory involve a core neural network, including the left angular gyrus.
  • Functional magnetic resonance imaging (fMRI) shows correlations but not causation for the left angular gyrus's role.
  • The critical function of the left angular gyrus in these abilities remains unconfirmed.

Purpose of the Study:

  • To investigate the causal role of the left angular gyrus in episodic simulation and memory.
  • To determine if disrupting the left angular gyrus impairs the ability to recall specific past and future experiences.

Main Methods:

  • Utilized MRI-guided transcranial magnetic stimulation (TMS) to temporarily disrupt the left angular gyrus.
  • Compared performance on episodic simulation and memory tasks with TMS applied to the left angular gyrus versus a control site (vertex).
  • Assessed the impact on internal (episodic) and external (semantic/irrelevant) details and task difficulty.

Main Results:

  • Disruption of the left angular gyrus significantly reduced internal details and increased external details during simulation and memory tasks.
  • Task difficulty increased after left angular gyrus TMS compared to vertex TMS.
  • Performance on a nonepisodic control task (free association) was unaffected by TMS site.

Conclusions:

  • Provides the first causal evidence that the left angular gyrus is critical for both episodic simulation and episodic memory.
  • Demonstrates the necessity of the left angular gyrus for generating detailed, relevant information in episodic tasks.
  • Highlights the importance of the left angular gyrus within the core network supporting episodic cognition.