Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pascal's Law01:04

Pascal's Law

11.8K
In 1653, the French philosopher and scientist Blaise Pascal published "Treatise on the Equilibrium of Liquids," which discussed the principles of static fluids. A static fluid is a fluid that is not in motion. When a fluid is not flowing, we say that the fluid is in static equilibrium. If the fluid is water, we say it is in hydrostatic equilibrium. For a fluid in static equilibrium, the net force on any part of the fluid must be zero; otherwise, the fluid will start to flow. Pascal...
11.8K
Laws of Logarithms II01:28

Laws of Logarithms II

320
Logarithmic laws provide essential tools for simplifying and evaluating exponential expressions, particularly in mathematical and applied settings where powers and repeated multiplication play a central role. Two important rules are the power law and the change-of-base formula, both allowing for transforming expressions into more manageable forms.The power law of logarithms states that the logarithm of a number raised to an exponent equals the exponent multiplied by the logarithm of the base...
320
Arc Length Function01:22

Arc Length Function

68
The arc length function represents the total distance traveled along a smooth curve measured from a fixed starting point to a variable endpoint. For curves that are continuous and differentiable, arc length provides a precise way to quantify distance when straight-line approximations are insufficient.To derive arc length, the curve is divided into many small segments. Each segment is approximated by a straight line whose length depends on the horizontal and vertical changes over that interval.
68
Application of Pascal's Law01:03

Application of Pascal's Law

11.1K
Pascal's experimentally proven observations—that a change in pressure applied to an enclosed fluid is transmitted undiminished throughout the fluid and to the walls of its container—provide the foundations for hydraulics, one of the most important developments in modern mechanical technology.
Hydraulic systems are used to operate automotive brakes, hydraulic jacks, and numerous other mechanical systems. We can derive a relationship between the forces in a simple hydraulic system...
11.1K
Lenz's Law01:15

Lenz's Law

6.5K
The direction in which the induced emf drives the current around a wire loop can be found through the negative sign. However, it is usually easier to determine this direction with Lenz's law, named in honor of its discoverer, Heinrich Lenz (1804–1865). Lenz's law states that the direction of the induced emf drives the current around a wire loop always to oppose the change in magnetic flux that causes the emf.
If a bar magnet is moved toward a coil such that the magnetic flux...
6.5K
P-value01:10

P-value

9.1K
P-value is one of the most crucial concepts in statistics.
P-value stands for the probability value.  P-value is the probability that, if the null hypothesis is true, the results from another randomly selected sample will be as extreme or more extreme as the results obtained from the given sample.
A large P-value calculated from the data indicates to  not reject the null hypothesis. But a higher P-value does not mean that the null hypothesis is true. The smaller the P-value, the more...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In search of a primitive signaling code.

Bio Systems·2019
Same author

Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial.

Autophagy·2016
Same author

Rapamycin treatment of Mandibuloacral dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics.

Aging·2014
Same author

Aggresome-Autophagy Involvement in a Sarcopenic Patient with Rigid Spine Syndrome and a p.C150R Mutation in FHL1 Gene.

Frontiers in aging neuroscience·2014
Same author

Growth on poly(L-lactic acid) porous scaffold preserves CD73 and CD90 immunophenotype markers of rat bone marrow mesenchymal stromal cells.

Journal of materials science. Materials in medicine·2014
Same author

Biodistribution and molecular studies on orally administered nanoparticle-AON complexes encapsulated with alginate aiming at inducing dystrophin rescue in mdx mice.

BioMed research international·2014

Related Experiment Video

Updated: Feb 26, 2026

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

8.4K

The lamin code.

Nadir M Maraldi1

  • 1National Research Council of Italy, Institute of Molecular Genetics, IGM-CNR-IOR, Bologna, Italy.

Bio Systems
|July 24, 2017
PubMed
Summary

Nuclear lamins, proteins forming the nuclear lamina, are crucial for cell differentiation. Their modifications may act as a "code" guiding tissue-specific cell development and evolution.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • Metazoa possess a nuclear envelope (NE) with lamins forming the nuclear lamina.
  • Lamin expression, particularly type-A lamins, correlates with organism complexity and early cell differentiation.
  • Altered lamin A expression patterns cause diseases known as laminopathies.

Purpose of the Study:

  • To explore the role of lamin posttranslational modifications in tissue-specific cell differentiation.
  • To investigate the hypothesis that lamin modifications constitute a regulatory code in metazoan cells.
  • To understand the link between differential lamin A expression and cell commitment.

Main Methods:

  • Analysis of lamin A expression patterns during cell differentiation.
Keywords:
Lamin posttranslational modificationsLaminopathiesNuclear envelopeNuclear laminaTissue-specific differentiation

More Related Videos

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

23.3K
A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System
10:27

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

Published on: June 12, 2019

9.2K

Related Experiment Videos

Last Updated: Feb 26, 2026

The Lambda Select cII Mutation Detection System
07:08

The Lambda Select cII Mutation Detection System

Published on: April 26, 2018

8.4K
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

23.3K
A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System
10:27

A Uniaxial Compression Experiment with CO2-Bearing Coal Using a Visualized and Constant-Volume Gas-Solid Coupling Test System

Published on: June 12, 2019

9.2K
  • Investigation of posttranslational modifications of lamin A.
  • Examination of the interaction between lamins, NE transmembrane proteins (NETs), and epigenetic repressors.

    • Main Results:

    • Differential lamin A expression is linked to tissue-specific cell commitment.
    • Posttranslational modifications of lamins suggest a potential regulatory code.
    • NETs and epigenetic repressors are involved in mediating the effects of lamin modifications.

    Conclusions:

    • Lamin posttranslational modifications may function as a "lamin code" essential for inducing tissue-specific cell differentiation in metazoans.
    • This code, though not fully deciphered, is supported by the involvement of NETs and epigenetic machinery.
    • The study suggests that lamin modification rules are part of the organic codes driving cell evolution.