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Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
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TFOS DEWS II Tear Film Report
Mark D P Willcox1, Pablo Argüeso2, Georgi A Georgiev3
1School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.
The Ocular Surface
|July 25, 2017
Summary
Dry eye disease (DED) involves changes in tear film composition and function. Research highlights increased tear osmolarity and altered proteins/mucins as key indicators for DED diagnosis and future study.
Area of Science:
- Ophthalmology
- Biochemistry
- Biophysics
Background:
- Dry eye disease (DED) is a prevalent ocular surface condition.
- The tear film is crucial for maintaining ocular surface health and comfort.
- Understanding tear film alterations in DED is vital for effective management.
Purpose of the Study:
- To review the role of the tear film in dry eye disease.
- To examine the biophysical and biochemical changes in tear film components during DED.
- To identify potential biomarkers for DED.
Main Methods:
- Comprehensive review of existing literature on tear film and DED.
- Analysis of biophysical and biochemical tear film properties.
- Evaluation of clinical characteristics of DED related to tear film integrity.
Main Results:
- DED is associated with reduced tear volume, faster tear film breakup, and increased evaporation.
- Tear film osmolarity is elevated in DED patients.
- Alterations in tear proteins and mucins show potential as DED biomarkers.
Conclusions:
- The tear film's complex composition and interactions are critical in DED.
- Biochemical and biophysical changes in tears offer diagnostic and research avenues.
- Further research is recommended to fully elucidate tear film dynamics in DED.
