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Bioactive Pimarane-Type Diterpenes from Marine Organisms.

Xiaoli Wang1,2, Haobing Yu1,3, Yixin Zhang1,3

  • 1Marine Biopharmaceutical Institute, Second Military Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.

Chemistry & Biodiversity
|July 25, 2017
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Summary

Marine organisms yield diverse pimarane diterpenes with significant biological activities. This review comprehensively details 80 marine-derived pimarane natural products, highlighting their structures and bioactivities.

Keywords:
BioactivityMarine organismsNatural productsPimarane diterpenesSecondary metabolites

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Area of Science:

  • Marine natural products chemistry
  • Organic chemistry
  • Pharmacology

Background:

  • Marine organisms are rich sources of bioactive natural products with unique chemical structures.
  • Pimarane diterpenes are a diverse class of natural products exhibiting various biological and pharmacological activities.
  • Marine-derived pimarane diterpenes are of significant interest due to their structural novelty and broad bioactivities.

Purpose of the Study:

  • To provide a comprehensive overview of marine-derived pimarane-type natural products.
  • To catalog the structures, names, bioactivities, and references of these compounds.
  • To consolidate existing knowledge on this important class of marine natural products.

Main Methods:

  • Literature review and data compilation.
  • Systematic search for marine-derived pimarane diterpenes.
  • Organization of information on chemical structures, biological activities, and references.

Main Results:

  • Identification and summarization of 80 marine-derived pimarane-type natural products.
  • Detailed information on the chemical structures and names of these compounds.
  • Compilation of their reported biological activities, including antimicrobial, antitumor, and antiproliferative effects.

Conclusions:

  • Marine-derived pimarane diterpenes represent a valuable resource for drug discovery.
  • This review serves as a foundational reference for researchers in marine natural products chemistry and pharmacology.
  • Further exploration of marine environments is crucial for discovering novel bioactive pimarane diterpenes.