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Updated: Feb 26, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
[Congenital hyperinsulinism of the newborn: a case report]
Josefina Sáez1, Juan Carlos Pattillo2, Pilar Orellana3
1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Abstract:
Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn and it is characterized by an inappropriately elevated insulin level in presence of hypoglycemia. Initial management is medical treatment, but if it fails, partial pancreatectomy is the surgical procedure of choice.
Objective:
To report a case of a newborn with CH to aware on this condition and update its multidisciplinary management.
Case Report:
The case of a full term newborn with severe symptomatic hypoglycemia unresponsive to medical treatment is reported . Ultrasonography and abdominal MRI were normal, Gallium 68 PET/CT showed uptake in the body of the pancreas. Laparoscopic corporocaudal pancreatectomy was performed. The patient resolved hypoglycemia and was discharged without incidents. Genetic study was consistent with focal CH, confirmed later by biopsy.
Discussion:
This case report exposes the clinical presentation of CH and its diagnosis. It emphasizes on the surgical treatment and the advantages of minimally invasive technique.
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