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Bromazepam as oral premedication. A comparison with lorazepam
Anaesthesia
|May 1, 1986
Summary
This study found bromazepam 6 mg and lorazepam 2 mg equally effective for pre-surgery sedation. Both drugs provided comparable patient outcomes regarding sedation, amnesia, and nausea.
Area of Science:
- Pharmacology
- Anesthesiology
- Clinical Trials
Background:
- Preoperative medication is crucial for patient comfort and managing surgical anxiety.
- Benzodiazepines are commonly used as premedicant agents due to their anxiolytic and sedative properties.
Purpose of the Study:
- To compare the efficacy and safety of bromazepam and lorazepam as oral premedicant agents.
- To evaluate objective and subjective patient responses to both drugs.
Main Methods:
- A double-blind, randomized trial involving 153 patients undergoing surgery.
- Patients received either bromazepam 6 mg or lorazepam 2 mg orally as pre-medication.
- Assessments included objective and subjective measures of sedation, amnesia, nausea, and vomiting.
Main Results:
- No statistically significant differences were observed between the bromazepam and lorazepam groups.
- Patient outcomes for sedation, amnesia, nausea, and vomiting were comparable across both treatment arms.
- Both agents demonstrated similar efficacy in the studied patient population.
Conclusions:
- Bromazepam 6 mg and lorazepam 2 mg are equally satisfactory premedicant drugs.
- The findings support the interchangeable use of these benzodiazepines for oral pre-medication.
- Further research could explore long-term effects or specific patient subgroups.